{"metadata":{"accession":"PF06047","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009269","hierarchy":null,"name":{"name":"NF-kappa-B-activating protein C-terminal domain","short":"Nkap_C"},"description":[{"text":"<p>This is the C-terminal domain found in NF-kappa-B-activating protein (Nkap) and a hypothetical open reading frame on chromosome 6, c6orf194. Functional studies in Nkap indicate that this domain is the HDAC3 binding domain and is required for transcriptional repression [[cite:PUB00075800]]. Nkap functions as a transcriptional repressor on Notch target genes, and is required for T cell development and acquisition of functional competency [[cite:PUB00075800],[cite:PUB00075801],[cite:PUB00075802]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075800":{"PMID":19409814,"ISBN":null,"volume":"30","issue":"5","year":2009,"title":"NKAP is a transcriptional repressor of notch signaling and is required for T cell development.","URL":null,"raw_pages":"696-707","medline_journal":"Immunity","ISO_journal":"Immunity","authors":["Pajerowski AG","Nguyen C","Aghajanian H","Shapiro MJ","Shapiro VS."],"DOI_URL":"http://dx.doi.org/10.1016/j.immuni.2009.02.011"},"PUB00075801":{"PMID":21624937,"ISBN":null,"volume":"208","issue":"6","year":2011,"title":"NKAP is required for T cell maturation and acquisition of functional competency.","URL":null,"raw_pages":"1291-304","medline_journal":"J Exp Med","ISO_journal":"J. Exp. Med.","authors":["Hsu FC","Pajerowski AG","Nelson-Holte M","Sundsbak R","Shapiro VS."],"DOI_URL":"http://dx.doi.org/10.1084/jem.20101874"},"PUB00075802":{"PMID":23481390,"ISBN":null,"volume":"4","issue":null,"year":2013,"title":"The transcriptional repressor NKAP is required for the development of iNKT cells.","URL":null,"raw_pages":"1582","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Thapa P","Das J","McWilliams D","Shapiro M","Sundsbak R","Nelson-Holte M","Tangen S","Anderson J","Desiderio S","Hiebert S","Sant'angelo DB","Shapiro VS."],"DOI_URL":"http://dx.doi.org/10.1038/ncomms2580"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":67,"interactions":0,"matches":2925,"pathways":0,"proteins":2915,"proteomes":2230,"sets":0,"structural_models":{"alphafold":2470},"structures":4,"taxa":6580},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":32,"alignment:full":2228},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}