{"metadata":{"accession":"PF06024","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009261","hierarchy":null,"name":{"name":"Orf78 (ac78)","short":"Orf78"},"description":[{"text":"<p>Family members include Autographa californica nuclear polyhedrosis virus (AcMNPV), AC78 or Orf78. AC78 is a late gene in the viral life cycle and encodes an envelope structural protein that plays an essential role in embedding the occlusion-derived virus (ODV) in the occlusion body [[cite:PUB00082587]]. Although AC78 is not essential for budding virus formation or nucleocapsid assembly and ODV formation, number are significantly reduced if the gene is knocked-out [[cite:PUB00082588]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00082587":{"PMID":23698311,"ISBN":null,"volume":"87","issue":"15","year":2013,"title":"The Autographa californica multiple nucleopolyhedrovirus ORF78 is essential for budded virus production and general occlusion body formation.","URL":null,"raw_pages":"8441-50","medline_journal":"J Virol","ISO_journal":"J. Virol.","authors":["Tao XY","Choi JY","Kim WJ","Lee JH","Liu Q","Kim SE","An SB","Lee SH","Woo SD","Jin BR","Je YH."],"DOI_URL":"http://dx.doi.org/10.1128/JVI.01290-13"},"PUB00082588":{"PMID":25087880,"ISBN":null,"volume":"191","issue":null,"year":2014,"title":"Disruption of the baculovirus core gene ac78 results in decreased production of multiple nucleocapsid-enveloped occlusion-derived virions and the failure of primary infection in vivo.","URL":null,"raw_pages":"70-82","medline_journal":"Virus Res","ISO_journal":"Virus Res.","authors":["Li SN","Wang JY","Yuan MJ","Yang K."],"DOI_URL":"http://dx.doi.org/10.1016/j.virusres.2014.07.019"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":97,"pathways":0,"proteins":97,"proteomes":95,"sets":0,"structural_models":{"alphafold":85},"structures":0,"taxa":291},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":23,"alignment:full":65},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}