{"metadata":{"accession":"PF06013","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR010310","hierarchy":null,"name":{"name":"Proteins of 100 residues with WXG","short":"WXG100"},"description":[{"text":"<p>ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. Homologues have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the [pfam:PF01580] domains in the YukA-like proteins [[cite:PUB00018371]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00044259":{"PMID":15657139,"ISBN":null,"volume":"102","issue":"4","year":2005,"title":"EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections.","URL":null,"raw_pages":"1169-74","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Burts ML","Williams WA","DeBord K","Missiakas DM."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.0405620102"},"PUB00152159":{"PMID":19299134,"ISBN":null,"volume":"17","issue":"4","year":2009,"title":"Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.","URL":null,"raw_pages":"139-45","medline_journal":"Trends Microbiol","ISO_journal":"Trends Microbiol","authors":["Desvaux M","Hebraud M","Talon R","Henderson IR."],"DOI_URL":"https://doi.org/10.1016/j.tim.2009.01.004"},"PUB00057458":{"PMID":20852931,"ISBN":null,"volume":"99","issue":"2","year":2011,"title":"New insights into the distribution of WXG100 protein secretion systems.","URL":null,"raw_pages":"127-31","medline_journal":"Antonie Van Leeuwenhoek","ISO_journal":"Antonie Van Leeuwenhoek","authors":["Sutcliffe IC."],"DOI_URL":"http://dx.doi.org/10.1007/s10482-010-9507-4"},"PUB00018371":{"PMID":11973144,"ISBN":null,"volume":"10","issue":"5","year":2002,"title":"The ESAT-6/WXG100 superfamily -- and a new Gram-positive secretion system?","URL":null,"raw_pages":"209-12","medline_journal":"Trends Microbiol","ISO_journal":"Trends Microbiol.","authors":["Pallen MJ."],"DOI_URL":"http://dx.doi.org/10.1016/S0966-842X(02)02345-4"},"PUB00152225":{"PMID":19674902,"ISBN":null,"volume":"17","issue":"8","year":2009,"title":"Outer membrane translocation: numerical protein secretion nomenclature in question in mycobacteria.","URL":null,"raw_pages":"338-40","medline_journal":"Trends Microbiol","ISO_journal":"Trends Microbiol","authors":["Desvaux M","Hebraud M","Talon R","Henderson IR."],"DOI_URL":"https://doi.org/10.1016/j.tim.2009.05.008"}},"set_info":{"accession":"CL0352","name":"EsxAB"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":57,"interactions":0,"matches":15663,"pathways":0,"proteins":15659,"proteomes":4540,"sets":1,"structural_models":{"alphafold":9559},"structures":24,"taxa":5854},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":69,"alignment:full":7068},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4j42","name":"The crystal structure of a secreted protein EsxB (Mutant Y65F) from Bacillus anthracis str. Sterne"}}}