{"metadata":{"accession":"PF06006","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009253","hierarchy":null,"name":{"name":"Bacterial protein of unknown function (DUF905)","short":"DUF905"},"description":[{"text":"<p>This family consists of several short hypothetical Enterobacteria proteins of unknown function. Structural analysis of the surface features of the protein YvyC has revealed a single cluster of highly conserved residues on the surface. Additionally, these residues fall into two groups which lie within the two largest of the three cavities identified over the surface. The conclusion from this is that these two cavities with, Leu 58, Glu 75, Ile 82, and Glu 83 and Pro 86, conserved, are likely to be important for the molecular function and reflect the cavities found on the surface of the FlaG proteins in [pfam:PF03646].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00069751":{"PMID":19455708,"ISBN":null,"volume":"76","issue":"4","year":2009,"title":"NMR structure of protein YvyC from Bacillus subtilis reveals unexpected structural similarity between two PFAM families.","URL":null,"raw_pages":"1037-41","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Eletsky A","Sukumaran DK","Xiao R","Acton TB","Rost B","Montelione GT","Szyperski T."],"DOI_URL":"http://dx.doi.org/10.1002/prot.22459"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":221,"pathways":0,"proteins":221,"proteomes":132,"sets":0,"structural_models":{"alphafold":124},"structures":1,"taxa":241},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":4,"alignment:full":45},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}