In B. subtilis, one small SOS response operon under the control of LexA, the yneA operon, is comprised of three genes: yneA, yneB, and ynzC [[cite:PUB00053936]]. This family consists of several short, hypothetical bacterial proteins of unknown function. These proteins are mainly found in gram-positive firmicutes. Structures show that the N-terminus is composed of two alpha helices forming a helix-loop-helix motif. The structure of ynzC from B. subtilis forms a trimeric complex [[cite:PUB00047592]]. Structural modelling suggests this domain may bind nucleic acids [[cite:PUB00070793]]. This family is also known as UPF0291.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00047592":{"PMID":18431750,"ISBN":null,"volume":"72","issue":"1","year":2008,"title":"Solution NMR structure of the SOS response protein YnzC from Bacillus subtilis.","URL":null,"raw_pages":"526-30","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Aramini JM","Sharma S","Huang YJ","Swapna GV","Ho CK","Shetty K","Cunningham K","Ma LC","Zhao L","Owens LA","Jiang M","Xiao R","Liu J","Baran MC","Acton TB","Rost B","Montelione GT."],"DOI_URL":"http://dx.doi.org/10.1002/prot.22064"},"PUB00053936":{"PMID":12581363,"ISBN":null,"volume":"47","issue":"4","year":2003,"title":"Identification of a protein, YneA, responsible for cell division suppression during the SOS response in Bacillus subtilis.","URL":null,"raw_pages":"1113-22","medline_journal":"Mol Microbiol","ISO_journal":"Mol. Microbiol.","authors":["Kawai Y","Moriya S","Ogasawara N."],"DOI_URL":"http://dx.doi.org/10.1046/j.1365-2958.2003.03360.x"},"PUB00070793":{"PMID":21348639,"ISBN":null,"volume":"15","issue":"7-8","year":2011,"title":"Ab initio modeling led annotation suggests nucleic acid binding function for many DUFs.","URL":null,"raw_pages":"431-8","medline_journal":"OMICS","ISO_journal":"OMICS","authors":["Rigden DJ."],"DOI_URL":"http://dx.doi.org/10.1089/omi.2010.0122"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":9,"interactions":0,"matches":3234,"pathways":0,"proteins":3234,"proteomes":2870,"sets":0,"structural_models":{"alphafold":2133},"structures":3,"taxa":4172},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":54,"alignment:full":1592},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}