{"metadata":{"accession":"PF05978","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR010291","hierarchy":null,"name":{"name":"Ion channel regulatory protein UNC-93","short":"UNC-93"},"description":[{"text":"<p>The proteins in this family are represented by UNC-93 from Caenorhabditis elegans and also includes protein unc-93 homologue A (UNC93A), protein unc-93 homologue B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain- containing protein 11 or protein ET). UNC-93 colocalizes with SUP-10 and SUP-9 within muscle cells. UNC-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans [[cite:PUB00053696]]. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades [[cite:PUB00097046]]. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons [[cite:PUB00097045]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00097045":{"PMID":27272503,"ISBN":null,"volume":"11","issue":"6","year":2016,"title":"The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis.","URL":null,"raw_pages":"e0156912","medline_journal":"PLoS One","ISO_journal":"PLoS One","authors":["Perland E","Lekholm E","Eriksson MM","Bagchi S","Arapi V","Fredriksson R."],"DOI_URL":null},"PUB00053696":{"PMID":14534247,"ISBN":null,"volume":"23","issue":"27","year":2003,"title":"sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans.","URL":null,"raw_pages":"9133-45","medline_journal":"J Neurosci","ISO_journal":"J. Neurosci.","authors":["de la Cruz IP","Levin JZ","Cummins C","Anderson P","Horvitz HR."],"DOI_URL":null},"PUB00097046":{"PMID":27458005,"ISBN":null,"volume":"128","issue":"12","year":2016,"title":"Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo.","URL":null,"raw_pages":"1604-8","medline_journal":"Blood","ISO_journal":"Blood","authors":["Wang JQ","Beutler B","Goodnow CC","Horikawa K."],"DOI_URL":null}},"set_info":{"accession":"CL0015","name":"MFS"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":156,"interactions":0,"matches":11823,"pathways":0,"proteins":11159,"proteomes":2949,"sets":1,"structural_models":{"alphafold":9617},"structures":0,"taxa":8050},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":9,"alignment:full":8917},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}