This protein family is found in bacteria, including Protein YciF from Escherichia coli. This protein is produced by bacteria in response to stress conditions. It adopts a dimeric configuration in which each monomer shows five alpha-helices. Its function is still unknown [[cite:PUB00041161]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00041161":{"PMID":17001035,"ISBN":null,"volume":"15","issue":"11","year":2006,"title":"The crystal structure of the E. coli stress protein YciF.","URL":null,"raw_pages":"2605-11","medline_journal":"Protein Sci","ISO_journal":"Protein Sci.","authors":["Hindupur A","Liu D","Zhao Y","Bellamy HD","White MA","Fox RO."],"DOI_URL":"http://dx.doi.org/10.1110/ps.062307706"}},"set_info":{"accession":"CL0044","name":"Ferritin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":15,"interactions":0,"matches":7244,"pathways":0,"proteins":7232,"proteomes":3560,"sets":1,"structural_models":{"alphafold":4705},"structures":6,"taxa":5175},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":42,"alignment:full":3271},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2gs4","name":"The crystal structure of the E.coli stress protein YciF."}}}