{"metadata":{"accession":"PF05971","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR010286","hierarchy":null,"name":{"name":"RNA methyltransferase","short":"Methyltransf_10"},"description":[{"text":"<p>This family includes ribosomal RNA large subunit methyltransferase F, and related proteins, including methyltransferase-like protein 16 (METTL16). METTL16 is a conserved RNA methyltransferase which interacts specifically with the MALAT1 triple helix. METTL16 shows nuclear localisation [[cite:PUB00085149]]. Another functional study indicates that METTL16 regulates expression of human MAT2A, which encodes the SAM synthetase expressed in most cells. Furthermore, results indicate that METTL16 is the long-unknown methyltransferase for the U6 spliceosomal small nuclear RNA (snRNA) and it has evolved an additional function in vertebrates to control SAM homeostasis by post-transcriptionally regulating SAM synthetase gene expression [[cite:PUB00086421]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00086421":{"PMID":28525753,"ISBN":null,"volume":"169","issue":"5","year":2017,"title":"The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.","URL":null,"raw_pages":"824-835.e14","medline_journal":"Cell","ISO_journal":"Cell","authors":["Pendleton KE","Chen B","Liu K","Hunter OV","Xie Y","Tu BP","Conrad NK."],"DOI_URL":"https://doi.org/10.1016/j.cell.2017.05.003"},"PUB00085149":{"PMID":27872311,"ISBN":null,"volume":"113","issue":"49","year":2016,"title":"Methyltransferase-like protein 16 binds the 3'-terminal triple helix of MALAT1 long noncoding RNA.","URL":null,"raw_pages":"14013-14018","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Brown JA","Kinzig CG","DeGregorio SJ","Steitz JA."],"DOI_URL":"https://doi.org/10.1073/pnas.1614759113"}},"set_info":{"accession":"CL0063","name":"NADP_Rossmann"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":87,"interactions":0,"matches":7961,"pathways":0,"proteins":7120,"proteomes":6099,"sets":1,"structural_models":{"alphafold":5338},"structures":31,"taxa":12386},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":4,"alignment:full":4801},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2h00","name":"Human methyltransferase 10 domain containing protein"}}}