{"metadata":{"accession":"PF05970","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR010285","hierarchy":null,"name":{"name":"PIF1-like helicase","short":"PIF1"},"description":[{"text":"<p>This family includes homologues of the PIF1 helicase, which inhibits telomerase activity and is cell cycle regulated [[cite:PUB00053693],[cite:PUB00053694],[cite:PUB00151827],[cite:PUB00151828]]. This family includes a large number of largely uncharacterised plant proteins.  This entry includes a P-loop motif that is involved in nucleotide binding.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00151828":{"PMID":29202194,"ISBN":null,"volume":"46","issue":"3","year":2018,"title":"Insights into the structural and mechanistic basis of multifunctional S. cerevisiae Pif1p helicase.","URL":null,"raw_pages":"1486-1500","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res","authors":["Lu KY","Chen WF","Rety S","Liu NN","Wu WQ","Dai YX","Li D","Ma HY","Dou SX","Xi XG."],"DOI_URL":null},"PUB00151827":{"PMID":30698796,"ISBN":null,"volume":"47","issue":"6","year":2019,"title":"Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.","URL":null,"raw_pages":"3208-3222","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res","authors":["Dehghani-Tafti S","Levdikov V","Antson AA","Bax B","Sanders CM."],"DOI_URL":null},"PUB00053693":{"PMID":17172855,"ISBN":null,"volume":"5","issue":"23","year":2006,"title":"Human PIF helicase is cell cycle regulated and associates with telomerase.","URL":null,"raw_pages":"2796-804","medline_journal":"Cell Cycle","ISO_journal":"Cell Cycle","authors":["Mateyak MK","Zakian VA."],"DOI_URL":null},"PUB00053694":{"PMID":16522649,"ISBN":null,"volume":"34","issue":"5","year":2006,"title":"The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity.","URL":null,"raw_pages":"1393-404","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Zhang DH","Zhou B","Huang Y","Xu LX","Zhou JQ."],"DOI_URL":"http://dx.doi.org/10.1093/nar/gkl029"}},"set_info":{"accession":"CL0023","name":"P-loop_NTPase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1063,"interactions":0,"matches":27374,"pathways":0,"proteins":26740,"proteomes":5288,"sets":1,"structural_models":{"alphafold":18182},"structures":37,"taxa":11185},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":12,"alignment:full":20438},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}