{"metadata":{"accession":"PF05903","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR008580","hierarchy":null,"name":{"name":"PPPDE putative peptidase domain","short":"Peptidase_C97"},"description":[{"text":"<p>The PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes), consists of predicted thiol peptidases with a circularly permuted papain-like fold. The inference of the likely DUB function of the PPPDE superfamily proteins is based on the fusions of the catalytic domain to Ub-binding PUG (PUB)/UBA domains and a novel alpha-helical Ub-associated domain (the PUL domain, after PLAP, Ufd3p and Lub1p) [[cite:PUB00020916]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00020916":{"PMID":15483401,"ISBN":null,"volume":"3","issue":"11","year":2004,"title":"Novel predicted peptidases with a potential role in the ubiquitin signaling pathway.","URL":null,"raw_pages":"1440-50","medline_journal":"Cell Cycle","ISO_journal":"Cell Cycle","authors":["Iyer LM","Koonin EV","Aravind L."],"DOI_URL":null}},"set_info":{"accession":"CL0125","name":"Peptidase_CA"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":274,"interactions":0,"matches":13857,"pathways":0,"proteins":13767,"proteomes":3325,"sets":1,"structural_models":{"alphafold":11440},"structures":2,"taxa":8933},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":28,"alignment:full":9919},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2wp7","name":"Crystal structure of deSUMOylase(DUF862)"}}}