{"metadata":{"accession":"PF05871","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR008570","hierarchy":null,"name":{"name":"ESCRT-II complex subunit","short":"ESCRT-II"},"description":[{"text":"<p>This family of conserved eukaryotic proteins are subunits of the endosome associated complex ESCRT-II which recruits transport machinery for protein sorting at the multivesicular body (MVB) [[cite:PUB00019520]].  This protein complex transiently associates with the endosomal membrane and thereby initiates the formation of ESCRT-III, a membrane-associated protein complex that functions immediately downstream of ESCRT-II during sorting of MVB cargo. ESCRT-II in turn functions downstream of ESCRT-I, a protein complex that binds to ubiquitinated endosomal cargo [[cite:PUB00019520]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"VPS25","extract":"<p><b>Vacuolar protein-sorting-associated protein 25</b> is a protein that in humans is encoded by the <i>VPS25</i> gene.</p>","thumbnail":null}],"literature":{"PUB00019520":{"PMID":12194858,"ISBN":null,"volume":"3","issue":"2","year":2002,"title":"Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body.","URL":null,"raw_pages":"283-9","medline_journal":"Dev Cell","ISO_journal":"Dev. Cell","authors":["Babst M","Katzmann DJ","Snyder WB","Wendland B","Emr SD."],"DOI_URL":"http://dx.doi.org/10.1016/S1534-5807(02)00219-8"},"PUB00019521":{"PMID":15469844,"ISBN":null,"volume":"7","issue":"4","year":2004,"title":"ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes.","URL":null,"raw_pages":"559-69","medline_journal":"Dev Cell","ISO_journal":"Dev. Cell","authors":["Teo H","Perisic O","Gonzalez B","Williams RL."],"DOI_URL":"http://dx.doi.org/10.1016/j.devcel.2004.09.003"}},"set_info":{"accession":"CL0123","name":"HTH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":83,"interactions":0,"matches":3804,"pathways":0,"proteins":3782,"proteomes":3214,"sets":1,"structural_models":{"alphafold":3245},"structures":8,"taxa":8677},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":129,"alignment:full":2928},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"7pb9","name":"Crystal structure of tandem WH domains of Vps25 from Odinarchaeota"}}}