This family acts as a lysozyme (N-acetylmuramidase), [ec:3.2.1.17]. It contains a conserved EGGY motif near the N-terminus, the glutamic acid within this motif is essential for catalytic activity [[cite:PUB00109141]]. In bacteria, it may activate the secretion of large proteins via the breaking and rearrangement of the peptidoglycan layer during secretion [[cite:PUB00021044],[cite:PUB00109142]]. It is frequently found at the N-terminus of proteins containing a C-terminal [pfam:PF09374] domain.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Glycoside_hydrolase_family_108","extract":"In molecular biology, glycoside hydrolase family 108 is a family of glycoside hydrolases.
","thumbnail":null}],"literature":{"PUB00109141":{"PMID":17174325,"ISBN":null,"volume":"366","issue":"2","year":2007,"title":"Coliphage N4 N-acetylmuramidase defines a new family of murein hydrolases.","URL":null,"raw_pages":"406-19","medline_journal":"J Mol Biol","ISO_journal":"J Mol Biol","authors":["Stojkovic EA","Rothman-Denes LB."],"DOI_URL":null},"PUB00021044":{"PMID":16155206,"ISBN":null,"volume":"14","issue":"10","year":2005,"title":"COG3926 and COG5526: a tale of two new lysozyme-like protein families.","URL":null,"raw_pages":"2574-81","medline_journal":"Protein Sci","ISO_journal":"Protein Sci.","authors":["Pei J","Grishin NV."],"DOI_URL":"http://dx.doi.org/10.1110/ps.051656805"},"PUB00109142":{"PMID":7764692,"ISBN":null,"volume":"58","issue":"3","year":1994,"title":"Cloning and characterization of a pair of genes that stimulate the production and secretion of Zymomonas mobilis extracellular levansucrase and invertase.","URL":null,"raw_pages":"526-30","medline_journal":"Biosci Biotechnol Biochem","ISO_journal":"Biosci Biotechnol Biochem","authors":["Kondo Y","Toyoda A","Fukushi H","Yanase H","Tonomura K","Kawasaki H","Sakai T."],"DOI_URL":null}},"set_info":{"accession":"CL0037","name":"Lysozyme"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":35,"interactions":0,"matches":2895,"pathways":0,"proteins":2895,"proteomes":2293,"sets":1,"structural_models":{"alphafold":1838},"structures":6,"taxa":4020},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":79,"alignment:full":1697},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}