{"metadata":{"accession":"PF05769","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR008555","hierarchy":null,"name":{"name":"SIKE family","short":"SIKE"},"description":[{"text":"<p>This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) is a physiological suppressor of IKK-epsilon and TBK1, which are two IKK-related kinases involved in virus- and  TLR3-triggered activation of interferon regulatory factor 3 (IRF-3). Other members of this family are circulating cathodic antigen (CCA), found in Schistosoma mansoni (Blood fluke) [[cite:PUB00011317],[cite:PUB00059263]], and FGFR1 oncogene partner 2, which may be involved in wound healing pathway [[cite:PUB00059262]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00059261":{"PMID":16281057,"ISBN":null,"volume":"24","issue":"23","year":2005,"title":"SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.","URL":null,"raw_pages":"4018-28","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Huang J","Liu T","Xu LG","Chen D","Zhai Z","Shu HB."],"DOI_URL":"http://dx.doi.org/10.1038/sj.emboj.7600863"},"PUB00059263":{"PMID":7925469,"ISBN":null,"volume":"225","issue":"1","year":1994,"title":"The immunologically reactive O-linked polysaccharide chains derived from circulating cathodic antigen isolated from the human blood fluke Schistosoma mansoni have Lewis x as repeating unit.","URL":null,"raw_pages":"467-82","medline_journal":"Eur J Biochem","ISO_journal":"Eur. J. Biochem.","authors":["Van Dam GJ","Bergwerff AA","Thomas-Oates JE","Rotmans JP","Kamerling JP","Vliegenthart JF","Deelder AM."],"DOI_URL":"http://dx.doi.org/10.1111/j.1432-1033.1994.00467.x"},"PUB00059262":{"PMID":14527947,"ISBN":null,"volume":"278","issue":"51","year":2003,"title":"Oral fibroblast expression of wound-inducible transcript 3.0 (wit3.0) accelerates the collagen gel contraction in vitro.","URL":null,"raw_pages":"51527-34","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Sukotjo C","Lin A","Song K","Ogawa T","Wu B","Nishimura I."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M309616200"},"PUB00011317":{"PMID":10413050,"ISBN":null,"volume":"101","issue":"1-2","year":1999,"title":"Molecular cloning and characterization of the polypeptide backbone of Schistosoma mansoni circulating cathodic antigen.","URL":null,"raw_pages":"149-59","medline_journal":"Mol Biochem Parasitol","ISO_journal":"Mol. Biochem. Parasitol.","authors":["Abdeen HH","Attallah AF","Mansour MM","Harrison RA."],"DOI_URL":"http://dx.doi.org/10.1016/S0166-6851(99)00068-7"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":44,"interactions":0,"matches":3127,"pathways":0,"proteins":2933,"proteomes":1606,"sets":0,"structural_models":{"alphafold":2613},"structures":3,"taxa":5060},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":28,"alignment:full":2531},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6akl","name":"Crystal structure of Striatin3 in complex with SIKE1 Coiled-coil domain"}}}