{"metadata":{"accession":"PF05768","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR008554","hierarchy":null,"name":{"name":"Glutaredoxin-like domain (DUF836)","short":"Glrx-like"},"description":[{"text":"<p>These proteins are related to the [pfam:PF00462] family. This entry includes several viral glutaredoxins and many related bacterial and eukaryotic proteins of unknown function. The best characterised member is G4L ([swissprot:P68460]) from Vaccinia virus (strain Western Reserve/WR) (VACV), which is necessary for virion morphogenesis and replication [[cite:PUB00020627]]. This is a cytoplasmic protein which functions as a shuttle in a redox pathway between membrane-associated E10R and L1R or F9L [[cite:PUB00020628]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00020628":{"PMID":11752136,"ISBN":null,"volume":"76","issue":"2","year":2002,"title":"Vaccinia virus G4L glutaredoxin is an essential intermediate of a cytoplasmic disulfide bond pathway required for virion assembly.","URL":null,"raw_pages":"467-72","medline_journal":"J Virol","ISO_journal":"J. Virol.","authors":["White CL","Senkevich TG","Moss B."],"DOI_URL":"http://dx.doi.org/10.1128/JVI.76.2.467-472.2002"},"PUB00020627":{"PMID":10982364,"ISBN":null,"volume":"74","issue":"19","year":2000,"title":"A glutaredoxin, encoded by the G4L gene of vaccinia virus, is essential for virion morphogenesis.","URL":null,"raw_pages":"9175-83","medline_journal":"J Virol","ISO_journal":"J. Virol.","authors":["White CL","Weisberg AS","Moss B."],"DOI_URL":"http://dx.doi.org/10.1128/JVI.74.19.9175-9183.2000"}},"set_info":{"accession":"CL0172","name":"Thioredoxin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":53,"interactions":0,"matches":10669,"pathways":0,"proteins":10668,"proteomes":10193,"sets":1,"structural_models":{"alphafold":7176},"structures":6,"taxa":16954},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":32,"alignment:full":5821},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"8pr6","name":"Crystal structure of Corynebacterium glutamicum mycoredoxin-3 at 1.7 A resolution."}}}