{"metadata":{"accession":"PF05742","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR008551","hierarchy":null,"name":{"name":"Transport and Golgi organisation 2","short":"TANGO2"},"description":[{"text":"<p>In eukaryotes this family is predicted to play a role in protein secretion and Golgi organisation [[cite:PUB00075420]]. In plants this family includes [swissprot:A9X6Y0], which is involved in water permeability in the cuticles of fruit [[cite:PUB00075421]]. [swissprot:P54797] has been found to be expressed during early embryogenesis in mice [[cite:PUB00011316]]. This protein contains a conserved NRDE motif. This gene has been characterised in Drosophila melanogaster and named as transport and Golgi organisation 2, hence the name Tango2.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075420":{"PMID":16452979,"ISBN":null,"volume":"439","issue":"7076","year":2006,"title":"Functional genomics reveals genes involved in protein secretion and Golgi organization.","URL":null,"raw_pages":"604-7","medline_journal":"Nature","ISO_journal":"Nature","authors":["Bard F","Casano L","Mallabiabarrena A","Wallace E","Saito K","Kitayama H","Guizzunti G","Hu Y","Wendler F","Dasgupta R","Perrimon N","Malhotra V."],"DOI_URL":"http://dx.doi.org/10.1038/nature04377"},"PUB00011316":{"PMID":8268909,"ISBN":null,"volume":"2","issue":"10","year":1993,"title":"Isolation of a gene expressed during early embryogenesis from the region of 22q11 commonly deleted in DiGeorge syndrome.","URL":null,"raw_pages":"1577-82","medline_journal":"Hum Mol Genet","ISO_journal":"Hum. Mol. Genet.","authors":["Halford S","Wilson DI","Daw SC","Roberts C","Wadey R","Kamath S","Wickremasinghe A","Burn J","Goodship J","Mattei MG."],"DOI_URL":"http://dx.doi.org/10.1093/hmg/2.10.1577"},"PUB00075421":{"PMID":17877702,"ISBN":null,"volume":"52","issue":"4","year":2007,"title":"The identification of a gene (Cwp1), silenced during Solanum evolution, which causes cuticle microfissuring and dehydration when expressed in tomato fruit.","URL":null,"raw_pages":"627-39","medline_journal":"Plant J","ISO_journal":"Plant J.","authors":["Hovav R","Chehanovsky N","Moy M","Jetter R","Schaffer AA."],"DOI_URL":"http://dx.doi.org/10.1111/j.1365-313X.2007.03265.x"}},"set_info":{"accession":"CL0052","name":"NTN"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":86,"interactions":0,"matches":10698,"pathways":0,"proteins":10332,"proteomes":8215,"sets":1,"structural_models":{"alphafold":7660},"structures":3,"taxa":15243},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":96,"alignment:full":6483},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"8sv7","name":"The 1.53 Angstrom structure of human Tango2"}}}