{"metadata":{"accession":"PF05685","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR008538","hierarchy":null,"name":{"name":"Putative restriction endonuclease","short":"Uma2"},"description":[{"text":"<p>This entry includes a group of putative nuclease, including hypothetical protein TT1808 (also known as Uma2 or TTHA1514), an AT-rich DNA-binding protein from Thermus thermophilus. This domain has a 3-layer alpha/beta/alpha topology similar to that found in restriction endonucleases [[cite:PUB00035698]]. The nuclease domain is ubiquitously found in enzymes involved in metabolism of nucleic acids, mostly in nucleases with diverse biological functions [[cite:PUB00035699]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00035699":{"PMID":15720711,"ISBN":null,"volume":"6","issue":"1","year":2005,"title":"Identification of a new family of putative PD-(D/E)XK nucleases with unusual phylogenomic distribution and a new type of the active site.","URL":null,"raw_pages":"21","medline_journal":"BMC Genomics","ISO_journal":"BMC Genomics","authors":["Feder M","Bujnicki JM."],"DOI_URL":"http://dx.doi.org/10.1186/1471-2164-6-21"},"PUB00035698":{"PMID":17154156,"ISBN":null,"volume":"66","issue":"3","year":2007,"title":"Crystal structure of TTHA1657 (AT-rich DNA-binding protein; p25) from Thermus thermophilus HB8 at 2.16 A resolution.","URL":null,"raw_pages":"755-9","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Nakamura A","Sosa A","Komori H","Kita A","Miki K."],"DOI_URL":"http://dx.doi.org/10.1002/prot.21222"}},"set_info":{"accession":"CL0236","name":"PDDEXK"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":59,"interactions":0,"matches":35117,"pathways":0,"proteins":35097,"proteomes":4365,"sets":1,"structural_models":{"alphafold":20569},"structures":4,"taxa":6843},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":138,"alignment:full":21144},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"9y1l","name":"Crystal Structure of Putative Restriction Endonuclease Domain-Containing Protein from Leptospirillum ferriphilum YSK"}}}