{"metadata":{"accession":"PF05670","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR008532","hierarchy":null,"name":{"name":"NFACT protein RNA binding domain","short":"NFACT-R_1"},"description":[{"text":"<p>This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from [swissprot:O34693] where the N-terminal region is involved in this activity [[cite:PUB00011315]]. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain [[cite:PUB00091027]]. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00091027":{"PMID":24646681,"ISBN":null,"volume":"11","issue":"4","year":2014,"title":"A highly conserved family of domains related to the DNA-glycosylase fold helps predict multiple novel pathways for RNA modifications.","URL":null,"raw_pages":"360-72","medline_journal":"RNA Biol","ISO_journal":"RNA Biol","authors":["Burroughs AM","Aravind L."],"DOI_URL":"https://doi.org/10.4161/rna.28302"},"PUB00011315":{"PMID":8063411,"ISBN":null,"volume":"62","issue":"9","year":1994,"title":"Cloning, sequencing, and expression of a fibronectin/fibrinogen-binding protein from group A streptococci.","URL":null,"raw_pages":"3937-46","medline_journal":"Infect Immun","ISO_journal":"Infect. Immun.","authors":["Courtney HS","Li Y","Dale JB","Hasty DL."],"DOI_URL":"http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=8063411&action=stream&blobtype=pdf"}},"set_info":{"accession":"CL0684","name":"NFACT_RNA-bind"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":128,"interactions":0,"matches":13157,"pathways":0,"proteins":13115,"proteomes":8466,"sets":1,"structural_models":{"alphafold":10207},"structures":20,"taxa":17368},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":35,"alignment:full":8864},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}