{"metadata":{"accession":"PF05667","entry_id":null,"type":"coiled_coil","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR048348","hierarchy":null,"name":{"name":"CCDC22 protein coiled-coil region","short":"CCDC22_CC"},"description":[{"text":"<p>Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex [[cite:PUB00077065]]. It is part of the COMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer [[cite:PUB00077066]]. This entry also includes CCDC22 homologues from animals and plants.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00077065":{"PMID":23563313,"ISBN":null,"volume":"123","issue":"5","year":2013,"title":"CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling.","URL":null,"raw_pages":"2244-56","medline_journal":"J Clin Invest","ISO_journal":"J. Clin. Invest.","authors":["Starokadomskyy P","Gluck N","Li H","Chen B","Wallis M","Maine GN","Mao X","Zaidi IW","Hein MY","McDonald FJ","Lenzner S","Zecha A","Ropers HH","Kuss AW","McGaughran J","Gecz J","Burstein E."],"DOI_URL":"http://dx.doi.org/10.1172/JCI66466"},"PUB00077066":{"PMID":25355947,"ISBN":null,"volume":"26","issue":"1","year":2015,"title":"COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.","URL":null,"raw_pages":"91-103","medline_journal":"Mol Biol Cell","ISO_journal":"Mol. Biol. Cell","authors":["Phillips-Krawczak CA","Singla A","Starokadomskyy P","Deng Z","Osborne DG","Li H","Dick CJ","Gomez TS","Koenecke M","Zhang JS","Dai H","Sifuentes-Dominguez LF","Geng LN","Kaufmann SH","Hein MY","Wallis M","McGaughran J","Gecz J","Sluis Bv","Billadeau DD","Burstein E."],"DOI_URL":"http://dx.doi.org/10.1091/mbc.E14-06-1073"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":29,"interactions":0,"matches":1924,"pathways":0,"proteins":1802,"proteomes":1233,"sets":0,"structural_models":{"alphafold":1532},"structures":4,"taxa":4130},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":29,"alignment:full":1413},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}