{"metadata":{"accession":"PF05638","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR008514","hierarchy":null,"name":{"name":"Type VI secretion system effector, Hcp","short":"T6SS_HCP"},"description":[{"text":"<p>HCP is a family of proteins which are expressed in up to 1000 copies in Gram-negative bacteria. Together these copies aggregate into a needle-like shaft or tube that will penetrate other bacteria via a puncturing protein attached to its head [[cite:PUB00075434]] being part of the type VI secretion system [[cite:PUB00155386],[cite:PUB00054686]]. Initially Hcp forms a hexameric structure with a central channel of 40 Angstroms. These hexamers pile up one on top of each other forming nanotubes resembling the gp19 tail phage tube [[cite:PUB00034462]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00054686":{"PMID":20886112,"ISBN":null,"volume":"5","issue":"9","year":2010,"title":"Structural basis for the secretion of EvpC: a key type VI secretion system protein from Edwardsiella tarda.","URL":null,"raw_pages":"e12910","medline_journal":"PLoS One","ISO_journal":"PLoS ONE","authors":["Jobichen C","Chakraborty S","Li M","Zheng J","Joseph L","Mok YK","Leung KY","Sivaraman J."],"DOI_URL":"http://dx.doi.org/10.1371/journal.pone.0012910"},"PUB00034462":{"PMID":16763151,"ISBN":null,"volume":"312","issue":"5779","year":2006,"title":"A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus.","URL":null,"raw_pages":"1526-30","medline_journal":"Science","ISO_journal":"Science","authors":["Mougous JD","Cuff ME","Raunser S","Shen A","Zhou M","Gifford CA","Goodman AL","Joachimiak G","Ordonez CL","Lory S","Walz T","Joachimiak A","Mekalanos JJ."],"DOI_URL":"http://dx.doi.org/10.1126/science.1128393"},"PUB00075434":{"PMID":24381728,"ISBN":null,"volume":"5","issue":null,"year":2013,"title":"The rise of the Type VI secretion system.","URL":null,"raw_pages":"52","medline_journal":"F1000Prime Rep","ISO_journal":"F1000Prime Rep","authors":["Filloux A."],"DOI_URL":"http://dx.doi.org/10.12703/P5-52"},"PUB00155386":{"PMID":26079269,"ISBN":null,"volume":"10","issue":"6","year":2015,"title":"Crystal Structure of Hcp from Acinetobacter baumannii: A Component of the Type VI Secretion System.","URL":null,"raw_pages":"e0129691","medline_journal":"PLoS One","ISO_journal":"PLoS One","authors":["Ruiz FM","Santillana E","Spinola-Amilibia M","Torreira E","Culebras E","Romero A."],"DOI_URL":"https://doi.org/10.1371/journal.pone.0129691"}},"set_info":{"accession":"CL0504","name":"Phage_barrel"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":36,"interactions":0,"matches":7781,"pathways":0,"proteins":7751,"proteomes":3501,"sets":1,"structural_models":{"alphafold":4734},"structures":22,"taxa":5255},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":115,"alignment:full":2597},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"8z7k","name":"Crystal structure of Hemolysin co-regulated protein 1 (Hcp1) VariantB from Burkholderia pseudomallei"}}}