{"metadata":{"accession":"PF05614","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR008500","hierarchy":null,"name":{"name":"Circovirus ORF3","short":"Circovir_ORF3"},"description":[{"text":"<p>This family consists porcine circovirus ORF3 protein which plays a role in modulating host cell signalling by binding to and degrading host RGS16 [[cite:PUB00097772]]. This protein is not necessary for virus replication [[cite:PUB00097771]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00097771":{"PMID":15956572,"ISBN":null,"volume":"79","issue":"13","year":2005,"title":"Characterization of a previously unidentified viral protein in porcine circovirus type 2-infected cells and its role in virus-induced apoptosis.","URL":null,"raw_pages":"8262-74","medline_journal":"J Virol","ISO_journal":"J Virol","authors":["Liu J","Chen I","Kwang J."],"DOI_URL":null},"PUB00097772":{"PMID":25575706,"ISBN":null,"volume":"96","issue":"Pt 5","year":2015,"title":"The ORF3 protein of porcine circovirus type 2 promotes secretion of IL-6 and IL-8 in porcine epithelial cells by facilitating proteasomal degradation of regulator of G protein signalling 16 through physical interaction.","URL":null,"raw_pages":"1098-1108","medline_journal":"J Gen Virol","ISO_journal":"J Gen Virol","authors":["Choi CY","Rho SB","Kim HS","Han J","Bae J","Lee SJ","Jung WW","Chun T."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":66,"pathways":0,"proteins":66,"proteomes":1,"sets":0,"structural_models":{"alphafold":2},"structures":0,"taxa":17},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":2,"alignment:full":1},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}