{"metadata":{"accession":"PF05608","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR008496","hierarchy":null,"name":{"name":"RTE1-like","short":"RTE1"},"description":[{"text":"<p>This entry, previously known as DUF778, represents  RTE1 (REVERSION-TO-ETHYLENE SENSITIVITY1) from Arabidopsis thaliana. RTE1 is positive regulator of the ETR1 ethylene receptor, leading to negative regulation of ethylene responses.[[cite:PUB00092499],[cite:PUB00092500]]. This entry also includes Arabidopsis RTE1 homologue, RTH, which acts via RTE1 in regulating ethylene responses and signaling [[cite:PUB00092501]]. This domain is also present in TMEM222 from animals which in humans plays a role in brain development and function and mutations result in autosomal recessive neurodevelopmental disorder. This domain has been identified as structurally similar to peptidase C97 domain ([pfam:PF05903]).</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00155829":{"PMID":33824500,"ISBN":null,"volume":"23","issue":"7","year":2021,"title":"Biallelic variants in TMEM222 cause a new autosomal recessive neurodevelopmental disorder.","URL":null,"raw_pages":"1246-1254","medline_journal":"Genet Med","ISO_journal":"Genet Med","authors":["Polla DL","Farazi Fard MA","Tabatabaei Z","Habibzadeh P","Levchenko OA","Nikuei P","Makrythanasis P","Hussain M","von Hardenberg S","Zeinali S","Fallah MS","Schuurs-Hoeijmakers JHM","Shahzad M","Fatima F","Fatima N","Kaat LD","Bruggenwirth HT","Fleming LR","Condie J","Ploski R","Pollak A","Pilch J","Demina NA","Chukhrova AL","Sergeeva VS","Venselaar H","Masri AT","Hamamy H","Santoni FA","Linda K","Ahmed ZM","Nadif Kasri N","de Brouwer APM","Bergmann AK","Hethey S","Yavarian M","Ansar M","Riazuddin S","Riazuddin S","Silawi M","Ruggeri G","Pirozzi F","Eftekhar E","Taghipour Sheshdeh A","Bahramjahan S","Mirzaa GM","Lavrov AV","Antonarakis SE","Faghihi MA","van Bokhoven H."],"DOI_URL":"https://doi.org/10.1038/s41436-021-01133-w"},"PUB00092501":{"PMID":28541511,"ISBN":null,"volume":"68","issue":"11","year":2017,"title":"Molecular association of Arabidopsis RTH with its homolog RTE1 in regulating ethylene signaling.","URL":null,"raw_pages":"2821-2832","medline_journal":"J Exp Bot","ISO_journal":"J. Exp. Bot.","authors":["Zheng F","Cui X","Rivarola M","Gao T","Chang C","Dong CH."],"DOI_URL":"https://doi.org/10.1093/jxb/erx175"},"PUB00092499":{"PMID":18643990,"ISBN":null,"volume":"56","issue":"3","year":2008,"title":"Involvement of RTE1 in conformational changes promoting ETR1 ethylene receptor signaling in Arabidopsis.","URL":null,"raw_pages":"423-31","medline_journal":"Plant J","ISO_journal":"Plant J.","authors":["Resnick JS","Rivarola M","Chang C."],"DOI_URL":"https://doi.org/10.1111/j.1365-313X.2008.03615.x"},"PUB00092500":{"PMID":16682642,"ISBN":null,"volume":"103","issue":"20","year":2006,"title":"REVERSION-TO-ETHYLENE SENSITIVITY1, a conserved gene that regulates ethylene receptor function in Arabidopsis.","URL":null,"raw_pages":"7917-22","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Resnick JS","Wen CK","Shockey JA","Chang C."],"DOI_URL":"https://doi.org/10.1073/pnas.0602239103"}},"set_info":{"accession":"CL0125","name":"Peptidase_CA"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":54,"interactions":0,"matches":3707,"pathways":0,"proteins":3287,"proteomes":1749,"sets":1,"structural_models":{"alphafold":2837},"structures":0,"taxa":5517},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":117,"alignment:full":2643},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}