{"metadata":{"accession":"PF05600","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR008491","hierarchy":null,"name":{"name":"CDK5 regulatory subunit-associated protein 3","short":"CDK5RAP3"},"description":[{"text":"<p>This family contains several eukaryotic sequences such as CDK5RAP3 (also known as C53 or LZAP) which serves as a probable tumour suppressor. Initially identified as a CDK5R1 interactor controlling cell proliferation [[cite:PUB00086010],[cite:PUB00086014]]. It negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation [[cite:PUB00043152],[cite:PUB00086011]]. It also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint [[cite:PUB00086012],[cite:PUB00086013]]. It has been shown to bind Wip1 and stimulates its phosphatase activity [[cite:PUB00086015]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00086013":{"PMID":19223857,"ISBN":null,"volume":"19","issue":"4","year":2009,"title":"Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation.","URL":null,"raw_pages":"458-68","medline_journal":"Cell Res","ISO_journal":"Cell Res.","authors":["Jiang H","Wu J","He C","Yang W","Li H."],"DOI_URL":"https://doi.org/10.1038/cr.2009.14"},"PUB00086011":{"PMID":20228063,"ISBN":null,"volume":"285","issue":"20","year":2010,"title":"A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling.","URL":null,"raw_pages":"15126-36","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Wu J","Lei G","Mei M","Tang Y","Li H."],"DOI_URL":"https://doi.org/10.1074/jbc.M110.110619"},"PUB00086015":{"PMID":28027003,"ISBN":null,"volume":"16","issue":"2","year":2017,"title":"LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro.","URL":null,"raw_pages":"213-223","medline_journal":"Cell Cycle","ISO_journal":"Cell Cycle","authors":["Wamsley JJ","Issaeva N","An H","Lu X","Donehower LA","Yarbrough WG."],"DOI_URL":"https://doi.org/10.1080/15384101.2016.1261767"},"PUB00086010":{"PMID":12054757,"ISBN":null,"volume":"294","issue":"1","year":2002,"title":"A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart.","URL":null,"raw_pages":"161-6","medline_journal":"Biochem Biophys Res Commun","ISO_journal":"Biochem. Biophys. Res. Commun.","authors":["Chen J","Liu B","Liu Y","Han Y","Yu H","Zhang Y","Lu L","Zhen Y","Hui R."],"DOI_URL":"https://doi.org/10.1016/S0006-291X(02)00446-1"},"PUB00086014":{"PMID":12737517,"ISBN":null,"volume":"13","issue":"2","year":2003,"title":"Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein.","URL":null,"raw_pages":"83-91","medline_journal":"Cell Res","ISO_journal":"Cell Res.","authors":["Xie YH","He XH","Tang YT","Li JJ","Pan ZM","Qin WX","Wan DF","Gu JR."],"DOI_URL":"https://doi.org/10.1038/sj.cr.7290153"},"PUB00086012":{"PMID":15790566,"ISBN":null,"volume":"280","issue":"21","year":2005,"title":"Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint.","URL":null,"raw_pages":"20651-9","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Jiang H","Luo S","Li H."],"DOI_URL":"https://doi.org/10.1074/jbc.M413431200"},"PUB00043152":{"PMID":17785205,"ISBN":null,"volume":"12","issue":"3","year":2007,"title":"LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB.","URL":null,"raw_pages":"239-51","medline_journal":"Cancer Cell","ISO_journal":"Cancer Cell","authors":["Wang J","An H","Mayo MW","Baldwin AS","Yarbrough WG."],"DOI_URL":"http://dx.doi.org/10.1016/j.ccr.2007.07.002"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":39,"interactions":0,"matches":2827,"pathways":0,"proteins":2603,"proteomes":1694,"sets":0,"structural_models":{"alphafold":2226},"structures":5,"taxa":5363},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":39,"alignment:full":2102},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}