{"metadata":{"accession":"PF05571","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR008485","hierarchy":null,"name":{"name":"JNK1/MAPK8-associated membrane protein","short":"JAMP"},"description":[{"text":"<p>This family consists of several eukaryotic proteins including JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein. It associates with JNK1 through its C-terminal domain and regulates the duration of JNK1 activity in response to diverse stress stimuli [[cite:PUB00086473]]. It is an important component for coordinated clearance of misfolded proteins from the ER [[cite:PUB00086474],[cite:PUB00086475]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00086475":{"PMID":19269966,"ISBN":null,"volume":"284","issue":"18","year":2009,"title":"Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP).","URL":null,"raw_pages":"12099-109","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Tcherpakov M","Delaunay A","Toth J","Kadoya T","Petroski MD","Ronai ZA."],"DOI_URL":"https://doi.org/10.1074/jbc.M808222200"},"PUB00086474":{"PMID":18784250,"ISBN":null,"volume":"19","issue":"11","year":2008,"title":"JAMP optimizes ERAD to protect cells from unfolded proteins.","URL":null,"raw_pages":"5019-28","medline_journal":"Mol Biol Cell","ISO_journal":"Mol. Biol. Cell","authors":["Tcherpakov M","Broday L","Delaunay A","Kadoya T","Khurana A","Erdjument-Bromage H","Tempst P","Qiu XB","DeMartino GN","Ronai Z."],"DOI_URL":"https://doi.org/10.1091/mbc.E08-08-0839"},"PUB00086473":{"PMID":16166642,"ISBN":null,"volume":"25","issue":"19","year":2005,"title":"JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity.","URL":null,"raw_pages":"8619-30","medline_journal":"Mol Cell Biol","ISO_journal":"Mol. Cell. Biol.","authors":["Kadoya T","Khurana A","Tcherpakov M","Bromberg KD","Didier C","Broday L","Asahara T","Bhoumik A","Ronai Z."],"DOI_URL":"https://doi.org/10.1128/MCB.25.19.8619-8630.2005"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":29,"interactions":0,"matches":1806,"pathways":0,"proteins":1738,"proteomes":1217,"sets":0,"structural_models":{"alphafold":1550},"structures":0,"taxa":3997},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":23,"alignment:full":1374},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}