{"metadata":{"accession":"PF05527","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR008477","hierarchy":null,"name":{"name":"Tumor necrosis factor alpha-induced protein 8-like","short":"TNFAIP8"},"description":[{"text":"<p>This family includes human tumor necrosis factor alpha-induced protein 8-like (TNFAIP8) and similar proteins mainly found in animals. TNFAIP8 functions as a negative mediator of apoptosis and may play a role in tumour progression. Proteins in this family adopt an all-alpha configuration.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00160688":{"PMID":36898854,"ISBN":null,"volume":"41","issue":"23","year":2023,"title":"Structural insight into TIPE1 functioning as a lipid transfer protein.","URL":null,"raw_pages":"14049-14062","medline_journal":"J Biomol Struct Dyn","ISO_journal":"J Biomol Struct Dyn","authors":["Cao S","Zhang Y","Jiang H","Hou X","Wang W."],"DOI_URL":"https://doi.org/10.1080/07391102.2023.2187641"},"PUB00160687":{"PMID":30401901,"ISBN":null,"volume":"9","issue":"1","year":2018,"title":"Structural basis of Gip1 for cytosolic sequestration of G protein in wide-range chemotaxis.","URL":null,"raw_pages":"4635","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Miyagawa T","Koteishi H","Kamimura Y","Miyanaga Y","Takeshita K","Nakagawa A","Ueda M."],"DOI_URL":"https://doi.org/10.1038/s41467-018-07035-x"},"PUB00051863":{"PMID":19079267,"ISBN":null,"volume":"16","issue":"1","year":2009,"title":"Crystal structure of TIPE2 provides insights into immune homeostasis.","URL":null,"raw_pages":"89-90","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat. Struct. Mol. Biol.","authors":["Zhang X","Wang J","Fan C","Li H","Sun H","Gong S","Chen YH","Shi Y."],"DOI_URL":"http://dx.doi.org/10.1038/nsmb.1522"},"PUB00160685":{"PMID":25242044,"ISBN":null,"volume":"26","issue":"4","year":2014,"title":"TIPE3 is the transfer protein of lipid second messengers that promote cancer.","URL":null,"raw_pages":"465-78","medline_journal":"Cancer Cell","ISO_journal":"Cancer Cell","authors":["Fayngerts SA","Wu J","Oxley CL","Liu X","Vourekas A","Cathopoulis T","Wang Z","Cui J","Liu S","Sun H","Lemmon MA","Zhang L","Shi Y","Chen YH."],"DOI_URL":"https://doi.org/10.1016/j.ccr.2014.07.025"},"PUB00160686":{"PMID":28740220,"ISBN":null,"volume":"7","issue":"1","year":2017,"title":"The Tnfaip8-PE complex is a novel upstream effector in the anti-autophagic action of insulin.","URL":null,"raw_pages":"6248","medline_journal":"Sci Rep","ISO_journal":"Sci Rep","authors":["Kim JS","Park J","Kim MS","Ha JY","Jang YW","Shin DH","Son JH."],"DOI_URL":"https://doi.org/10.1038/s41598-017-06576-3"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":24,"interactions":0,"matches":3831,"pathways":0,"proteins":3812,"proteomes":1267,"sets":0,"structural_models":{"alphafold":3414},"structures":6,"taxa":4156},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":38,"alignment:full":3053},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3f4m","name":"Crystal structure of TIPE2"}}}