{"metadata":{"accession":"PF05430","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR008471","hierarchy":null,"name":{"name":"S-adenosyl-L-methionine-dependent methyltransferase","short":"Methyltransf_30"},"description":[{"text":"<p>This family is a S-adenosyl-L-methionine (SAM)-dependent methyltransferase. It is often found in association with [pfam:PF01266], where it is responsible for catalysing the transfer of a methyl group from S-adenosyl-L-methionine to 5-aminomethyl-2-thiouridine to form 5-methylaminomethyl-2-thiouridine [[cite:PUB00043072],[cite:PUB00057501]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00057501":{"PMID":18186482,"ISBN":null,"volume":"71","issue":"4","year":2008,"title":"Sequence-structure-function analysis of the bifunctional enzyme MnmC that catalyses the last two steps in the biosynthesis of hypermodified nucleoside mnm5s2U in tRNA.","URL":null,"raw_pages":"2076-85","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Roovers M","Oudjama Y","Kaminska KH","Purta E","Caillet J","Droogmans L","Bujnicki JM."],"DOI_URL":"http://dx.doi.org/10.1002/prot.21918"},"PUB00043072":{"PMID":15247431,"ISBN":null,"volume":"10","issue":"8","year":2004,"title":"Identification of a bifunctional enzyme MnmC involved in the biosynthesis of a hypermodified uridine in the wobble position of tRNA.","URL":null,"raw_pages":"1236-42","medline_journal":"RNA","ISO_journal":"RNA","authors":["Bujnicki JM","Oudjama Y","Roovers M","Owczarek S","Caillet J","Droogmans L."],"DOI_URL":"http://dx.doi.org/10.1261/rna.7470904"}},"set_info":{"accession":"CL0063","name":"NADP_Rossmann"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":11,"interactions":0,"matches":7062,"pathways":0,"proteins":7062,"proteomes":6946,"sets":1,"structural_models":{"alphafold":4469},"structures":6,"taxa":9918},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":16,"alignment:full":3201},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}