{"metadata":{"accession":"PF05346","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR008010","hierarchy":null,"name":{"name":"Eukaryotic membrane protein family","short":"DUF747"},"description":[{"text":"<p>This family is a family of eukaryotic membrane proteins.  It was previously annotated as including a putative receptor for human cytomegalovirus gH [[cite:PUB00019476]] but this has has since been disputed [[cite:PUB00044752]]. Analysis of the mouse Tapt1 protein (transmembrane anterior posterior transformation 1) has shown it to be involved in patterning of the vertebrate axial skeleton.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00019476":{"PMID":10640539,"ISBN":null,"volume":"81","issue":"Pt 1","year":2000,"title":"Cloning and epitope mapping of a functional partial fusion receptor for human cytomegalovirus gH.","URL":null,"raw_pages":"27-35","medline_journal":"J Gen Virol","ISO_journal":"J. Gen. Virol.","authors":["Baldwin BR","Zhang CO","Keay S."],"DOI_URL":"http://vir.sgmjournals.org/cgi/content/abstract/81/1/27"},"PUB00044752":{"PMID":17151244,"ISBN":null,"volume":"175","issue":"2","year":2007,"title":"Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations.","URL":null,"raw_pages":"699-707","medline_journal":"Genetics","ISO_journal":"Genetics","authors":["Howell GR","Shindo M","Murray S","Gridley T","Wilson LA","Schimenti JC."],"DOI_URL":"http://dx.doi.org/10.1534/genetics.106.065177"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":84,"interactions":0,"matches":4980,"pathways":0,"proteins":4804,"proteomes":3258,"sets":0,"structural_models":{"alphafold":4083},"structures":0,"taxa":8637},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":106,"alignment:full":3833},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}