{"metadata":{"accession":"PF05300","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007964","hierarchy":null,"name":{"name":"MICOS complex subunit MIC19/MIC25","short":"MIC19_MIC25"},"description":[{"text":"<p>MIC19 (also known as ChChd3) and MIC25 (also known as ChChd6) are components of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane [[cite:PUB00086469],[cite:PUB00086470],[cite:PUB00093460]]. MIC19 plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology [[cite:PUB00086469]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00093460":{"PMID":27245231,"ISBN":null,"volume":"367","issue":"1","year":2017,"title":"The MICOS complex of human mitochondria.","URL":null,"raw_pages":"83-93","medline_journal":"Cell Tissue Res","ISO_journal":"Cell Tissue Res.","authors":["Kozjak-Pavlovic V."],"DOI_URL":null},"PUB00086469":{"PMID":21081504,"ISBN":null,"volume":"286","issue":"4","year":2011,"title":"ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function.","URL":null,"raw_pages":"2918-32","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Darshi M","Mendiola VL","Mackey MR","Murphy AN","Koller A","Perkins GA","Ellisman MH","Taylor SS."],"DOI_URL":"https://doi.org/10.1074/jbc.M110.171975"},"PUB00086470":{"PMID":22228767,"ISBN":null,"volume":"287","issue":"10","year":2012,"title":"CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology.","URL":null,"raw_pages":"7411-26","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["An J","Shi J","He Q","Lui K","Liu Y","Huang Y","Sheikh MS."],"DOI_URL":"https://doi.org/10.1074/jbc.M111.277103"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":18,"interactions":0,"matches":2774,"pathways":0,"proteins":2697,"proteomes":724,"sets":0,"structural_models":{"alphafold":2422},"structures":0,"taxa":2240},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":26,"alignment:full":2230},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}