{"metadata":{"accession":"PF05258","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007922","hierarchy":null,"name":{"name":"Dna[CI] antecedent, DciA","short":"DciA"},"description":[{"text":"<p>This family contains several actinomycete proteins. Family members such as DciA (dna[CI] antecedent) found in Pseudomonas aeruginosa, has been shown to share a common function with DnaC (in Escherichia coli) and DnaI (in Bacillus subtilis), acting as a replicative helicase. Furthermore, functional analysis revealed that DciA is essential for replication initiation and protein depletion resulted in a blockage of the initiation of replication after the formation of the open complex [[cite:PUB00085163]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00085163":{"PMID":27830752,"ISBN":null,"volume":"7","issue":null,"year":2016,"title":"DciA is an ancestral replicative helicase operator essential for bacterial replication initiation.","URL":null,"raw_pages":"13271","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Brezellec P","Vallet-Gely I","Possoz C","Quevillon-Cheruel S","Ferat JL."],"DOI_URL":"https://doi.org/10.1038/ncomms13271"}},"set_info":{"accession":"CL0424","name":"T3SS-hook"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":11,"interactions":0,"matches":12812,"pathways":0,"proteins":12811,"proteomes":12625,"sets":1,"structural_models":{"alphafold":8175},"structures":2,"taxa":17544},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":77,"alignment:full":6512},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"7ykm","name":"Structure of DciA DUF721 domain from Deinococcus radiodurans"}}}