{"metadata":{"accession":"PF05197","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007866","hierarchy":null,"name":{"name":"TRIC channel","short":"TRIC"},"description":[{"text":"<p>TRIC (trimeric intracellular cation) channels are differentially expressed in intracellular stores in animal cell types. TRIC subtypes contain three proposed transmembrane segments, and form homo-trimers with a bullet-like structure. Electrophysiological measurements with purified TRIC preparations identify a monovalent cation-selective channel [[cite:PUB00053854]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00053854":{"PMID":17611541,"ISBN":null,"volume":"448","issue":"7149","year":2007,"title":"TRIC channels are essential for Ca2+ handling in intracellular stores.","URL":null,"raw_pages":"78-82","medline_journal":"Nature","ISO_journal":"Nature","authors":["Yazawa M","Ferrante C","Feng J","Mio K","Ogura T","Zhang M","Lin PH","Pan Z","Komazaki S","Kato K","Nishi M","Zhao X","Weisleder N","Sato C","Ma J","Takeshima H."],"DOI_URL":"http://dx.doi.org/10.1038/nature05928"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":37,"interactions":0,"matches":2720,"pathways":0,"proteins":2675,"proteomes":1395,"sets":0,"structural_models":{"alphafold":2374},"structures":12,"taxa":4498},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":30,"alignment:full":2130},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6iyx","name":"Crystal Structure Analysis of a Eukaryotic Membrane Protein"}}}