The proteins in this family are functionally uncharacterised. The proteins are around 450 amino acids long and includes Streptococcus pneumoniae Sp0239 which is structurally similar to ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL). It is likely that this family represents a group of glycerol-3-phosphate dehydrogenases.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0339","name":"PFL-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":7,"interactions":0,"matches":2799,"pathways":0,"proteins":2789,"proteomes":2660,"sets":1,"structural_models":{"alphafold":2063},"structures":1,"taxa":4756},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":99,"alignment:full":1675},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}