{"metadata":{"accession":"PF05114","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007801","hierarchy":null,"name":{"name":"RiPP precursor modification enzyme MbnB/TglH/ChrH","short":"MbnB_TglH_ChrH"},"description":[{"text":"<p>This entry represents a family of multinuclear iron-containing proteins which are post-translational modification enzymes involved in the biosynthesis of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products, including the precursor modification enzymes MbnB, TglH, and ChrH, formerly known as DUF692 [[cite:PUB00153337],[cite:PUB00106909]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00153338":{"PMID":37252350,"ISBN":null,"volume":"9","issue":"5","year":2023,"title":"Macrocyclization and Backbone Rearrangement During RiPP Biosynthesis by a SAM-Dependent Domain-of-Unknown-Function 692.","URL":null,"raw_pages":"1008-1018","medline_journal":"ACS Cent Sci","ISO_journal":"ACS Cent Sci","authors":["Ayikpoe RS","Zhu L","Chen JY","Ting CP","van der Donk WA."],"DOI_URL":"https://doi.org/10.1021/acscentsci.3c00160"},"PUB00153337":{"PMID":35362960,"ISBN":null,"volume":"17","issue":"4","year":2022,"title":"Substrate Recognition by the Peptidyl-(<i>S</i>)-2-mercaptoglycine Synthase TglHI during 3-Thiaglutamate Biosynthesis.","URL":null,"raw_pages":"930-940","medline_journal":"ACS Chem Biol","ISO_journal":"ACS Chem Biol","authors":["McLaughlin MI","Yu Y","van der Donk WA."],"DOI_URL":"https://doi.org/10.1021/acschembio.2c00087"},"PUB00106909":{"PMID":35320042,"ISBN":null,"volume":"119","issue":"13","year":2022,"title":"A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis.","URL":null,"raw_pages":"e2123566119","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Park YJ","Jodts RJ","Slater JW","Reyes RM","Winton VJ","Montaser RA","Thomas PM","Dowdle WB","Ruiz A","Kelleher NL","Bollinger JM Jr","Krebs C","Hoffman BM","Rosenzweig AC."],"DOI_URL":null}},"set_info":{"accession":"CL0036","name":"TIM_barrel"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":10,"interactions":0,"matches":7269,"pathways":0,"proteins":7264,"proteomes":5572,"sets":1,"structural_models":{"alphafold":4336},"structures":10,"taxa":7824},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":139,"alignment:full":3356},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}