{"metadata":{"accession":"PF05093","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046408","hierarchy":null,"name":{"name":"Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis","short":"CIAPIN1"},"description":[{"text":"<p>Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homologue of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS) [[cite:PUB00055951]].  CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis [[cite:PUB00055952]]. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress [[cite:PUB00109169]]. These proteins consist of two domains, the N-terminal well-folded one, with a S-adenosylmethionine methyltransferase-like fold and the C-terminal more flexible domain, represented in this entry, which contains two highly conserved cysteine rich motifs that bind Fe-S clusters [[cite:PUB00067100],[cite:PUB00056284]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00056284":{"PMID":21700214,"ISBN":null,"volume":"18","issue":"6","year":2011,"title":"Anamorsin is a [2Fe-2S] cluster-containing substrate of the Mia40-dependent mitochondrial protein trapping machinery.","URL":null,"raw_pages":"794-804","medline_journal":"Chem Biol","ISO_journal":"Chem. Biol.","authors":["Banci L","Bertini I","Ciofi-Baffoni S","Boscaro F","Chatzi A","Mikolajczyk M","Tokatlidis K","Winkelmann J."],"DOI_URL":"http://dx.doi.org/10.1016/j.chembiol.2011.03.015"},"PUB00109169":{"PMID":19194512,"ISBN":null,"volume":"4","issue":"2","year":2009,"title":"A newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast.","URL":null,"raw_pages":"e4376","medline_journal":"PLoS One","ISO_journal":"PLoS One","authors":["Vernis L","Facca C","Delagoutte E","Soler N","Chanet R","Guiard B","Faye G","Baldacci G."],"DOI_URL":null},"PUB00055952":{"PMID":18299278,"ISBN":null,"volume":"29","issue":"8","year":2008,"title":"Adenovirus-delivered CIAPIN1 small interfering RNA inhibits HCC growth in vitro and in vivo.","URL":null,"raw_pages":"1587-93","medline_journal":"Carcinogenesis","ISO_journal":"Carcinogenesis","authors":["Li X","Pan Y","Fan R","Jin H","Han S","Liu J","Wu K","Fan D."],"DOI_URL":"http://dx.doi.org/10.1093/carcin/bgn052"},"PUB00055951":{"PMID":18625724,"ISBN":null,"volume":"28","issue":"18","year":2008,"title":"Dre2, a conserved eukaryotic Fe/S cluster protein, functions in cytosolic Fe/S protein biogenesis.","URL":null,"raw_pages":"5569-82","medline_journal":"Mol Cell Biol","ISO_journal":"Mol. Cell. Biol.","authors":["Zhang Y","Lyver ER","Nakamaru-Ogiso E","Yoon H","Amutha B","Lee DW","Bi E","Ohnishi T","Daldal F","Pain D","Dancis A."],"DOI_URL":"http://dx.doi.org/10.1128/MCB.00642-08"},"PUB00067100":{"PMID":23596212,"ISBN":null,"volume":"110","issue":"18","year":2013,"title":"Molecular view of an electron transfer process essential for iron-sulfur protein biogenesis.","URL":null,"raw_pages":"7136-41","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Banci L","Bertini I","Calderone V","Ciofi-Baffoni S","Giachetti A","Jaiswal D","Mikolajczyk M","Piccioli M","Winkelmann J."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.1302378110"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":90,"interactions":0,"matches":4936,"pathways":0,"proteins":4152,"proteomes":3289,"sets":0,"structural_models":{"alphafold":3590},"structures":0,"taxa":8763},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":56,"alignment:full":3912},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}