{"metadata":{"accession":"PF05078","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007770","hierarchy":null,"name":{"name":"Protein of unknown function (DUF679)","short":"DUF679"},"description":[{"text":"<p>This family includes members such as plant proteins AtDMPs 1-10 (Arabidopsis thaliana DUF679 domain membrane proteins 1 -10) [[cite:PUB00136742]]. The AtDMP proteins are predicted to have four transmembrane spans, with cytosolic amino- and carboxy-termini. DMP1 is a membrane protein that may be involved in membrane fission during breakdown of the ER and the tonoplast during leaf senescence and in membrane fusion during vacuole biogenesis in roots [[cite:PUB00086645]]. Several DMP proteins are expressed in senescing organs (DMP1, -3, -4) or tissues that will stall later in development (DMP1, -2, -4, -7). These expression patterns strongly suggest involvement of several DMPs in various programmed cell death processes, e.g. senescence, dehiscence and abscission [[cite:PUB00136742]]. AtDMP8 and AtDMP9 however, have been shown to facilitate gamete fusion during double fertilisation in flowering plants [[cite:PUB00093467]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00093467":{"PMID":30850817,"ISBN":null,"volume":"5","issue":"3","year":2019,"title":"Gamete fusion is facilitated by two sperm cell-expressed DUF679 membrane proteins.","URL":null,"raw_pages":"253-257","medline_journal":"Nat Plants","ISO_journal":"Nat Plants","authors":["Cyprys P","Lindemeier M","Sprunck S."],"DOI_URL":null},"PUB00136742":{"PMID":20712629,"ISBN":null,"volume":"12 Suppl 1","issue":null,"year":2010,"title":"Expression, localisation and phylogeny of a novel family of plant-specific membrane proteins.","URL":null,"raw_pages":"140-52","medline_journal":"Plant Biol (Stuttg)","ISO_journal":"Plant Biol (Stuttg)","authors":["Kasaras A","Kunze R."],"DOI_URL":null},"PUB00086645":{"PMID":22530652,"ISBN":null,"volume":"12","issue":null,"year":2012,"title":"Arabidopsis senescence-associated protein DMP1 is involved in membrane remodeling of the ER and tonoplast.","URL":null,"raw_pages":"54","medline_journal":"BMC Plant Biol","ISO_journal":"BMC Plant Biol.","authors":["Kasaras A","Melzer M","Kunze R."],"DOI_URL":"https://doi.org/10.1186/1471-2229-12-54"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":52,"interactions":0,"matches":4715,"pathways":0,"proteins":4584,"proteomes":395,"sets":0,"structural_models":{"alphafold":3757},"structures":0,"taxa":1097},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":82,"alignment:full":2991},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}