This domain, whose function is unknown, is found within a group of putative lipases. Proteins containing this domain include YOR059C (Lpl1) from budding yeasts. Lpl1 has been identified as a phospholipase B [[cite:PUB00073522]]. They contain an alpha/beta hydrolase fold.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00073522":{"PMID":25014274,"ISBN":null,"volume":"1842","issue":"10","year":2014,"title":"Identification of a phospholipase B encoded by the LPL1 gene in Saccharomyces cerevisiae.","URL":null,"raw_pages":"1383-92","medline_journal":"Biochim Biophys Acta","ISO_journal":"Biochim. Biophys. Acta","authors":["Selvaraju K","Rajakumar S","Nachiappan V."],"DOI_URL":"http://dx.doi.org/10.1016/j.bbalip.2014.06.013"}},"set_info":{"accession":"CL0028","name":"AB_hydrolase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":547,"interactions":0,"matches":16829,"pathways":0,"proteins":15503,"proteomes":4005,"sets":1,"structural_models":{"alphafold":10211},"structures":0,"taxa":10132},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":13,"alignment:full":12407},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}