This family consists of AT14A like proteins from Arabidopsis thaliana. At14a has a small domain that has sequence similarities to integrins from fungi, insects and humans. Transcripts of At14a are found in all Arabidopsis tissues and localises partly to the plasma membrane [[cite:PUB00010152]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00010152":{"PMID":10196471,"ISBN":null,"volume":"230","issue":"1","year":1999,"title":"Isolation and characterization of a cDNA clone from Arabidopsis thaliana with partial sequence similarity to integrins.","URL":null,"raw_pages":"33-40","medline_journal":"Gene","ISO_journal":"Gene","authors":["Nagpal P","Quatrano RS."],"DOI_URL":"http://dx.doi.org/10.1016/S0378-1119(99)00068-2"}},"set_info":{"accession":"CL0133","name":"AT14A-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":66,"interactions":0,"matches":3822,"pathways":0,"proteins":3710,"proteomes":378,"sets":1,"structural_models":{"alphafold":3001},"structures":0,"taxa":1035},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":2343},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}