{"metadata":{"accession":"PF05054","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007748","hierarchy":null,"name":{"name":"Autographa californica nuclear polyhedrosis virus (AcMNPV) protein","short":"AcMNPV_Ac109"},"description":[{"text":"<p>This domain family is found in viral proteins such as Ac109 from Autographa californica nuclear polyhedrosis virus (AcMNPV). The gene (Orf1090) is essential and transcribed late in virus assembly, and protein AC109 has been shown to be important for the transport of the budded virion to the host nucleus. In mutants lacking the AC109 gene, virions are unable to enter the nucleus and remain in the cytoplasm. Although addition of AC109 allowed virions to enter the nucleus, the occlusion bodies were empty, indicating that AC109 is also important for the production of infectious budded virus [[cite:PUB00082303]] [[cite:PUB00082304]]. The exact function of this domain family remains unknown.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00082304":{"PMID":23149091,"ISBN":null,"volume":"435","issue":"2","year":2013,"title":"Autographa californica M nucleopolyhedrovirus open reading frame 109 affects infectious budded virus production and nucleocapsid envelopment in the nucleus of cells.","URL":null,"raw_pages":"442-52","medline_journal":"Virology","ISO_journal":"Virology","authors":["Lehiy CJ","Wu W","Berretta MF","Passarelli AL."],"DOI_URL":"http://dx.doi.org/10.1016/j.virol.2012.10.015"},"PUB00082303":{"PMID":23049963,"ISBN":null,"volume":"7","issue":"9","year":2012,"title":"AcMNPV core gene ac109 is required for budded virion transport to the nucleus and for occlusion of viral progeny.","URL":null,"raw_pages":"e46146","medline_journal":"PLoS One","ISO_journal":"PLoS ONE","authors":["Alfonso V","Maroniche GA","Reca SR","Lopez MG","del Vas M","Taboga O."],"DOI_URL":"http://dx.doi.org/10.1371/journal.pone.0046146"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":157,"pathways":0,"proteins":100,"proteomes":100,"sets":0,"structural_models":{"alphafold":92},"structures":6,"taxa":203},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":2,"alignment:full":126},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}