{"metadata":{"accession":"PF05050","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR006342","hierarchy":null,"name":{"name":"Methyltransferase FkbM domain","short":"Methyltransf_21"},"description":[{"text":"<p>This domain is characterised by two well-conserved short regions separated by a variable region in both sequence and length. Proteins containing this domain have been characterised as methyltransferases. FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548 [[cite:PUB00009583]]. This domain is also found in other methyltransferases such as SdnD from the fungus Sordaria araneosa, involved in the biosynthesis of glycoside antibiotics with tetracyclic diterpene aglycone structure [[cite:PUB00089798]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00089798":{"PMID":27072286,"ISBN":null,"volume":"69","issue":"7","year":2016,"title":"Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386: characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase.","URL":null,"raw_pages":"541-8","medline_journal":"J Antibiot (Tokyo)","ISO_journal":"J. Antibiot.","authors":["Kudo F","Matsuura Y","Hayashi T","Fukushima M","Eguchi T."],"DOI_URL":"https://doi.org/10.1038/ja.2016.40"},"PUB00009583":{"PMID":8752344,"ISBN":null,"volume":"178","issue":"17","year":1996,"title":"Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520.","URL":null,"raw_pages":"5243-8","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Motamedi H","Shafiee A","Cai SJ","Streicher SL","Arison BH","Miller RR."],"DOI_URL":"http://jb.asm.org/cgi/content/abstract/178/17/5243"}},"set_info":{"accession":"CL0063","name":"NADP_Rossmann"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":576,"interactions":0,"matches":21481,"pathways":0,"proteins":21317,"proteomes":8683,"sets":1,"structural_models":{"alphafold":14912},"structures":1,"taxa":15058},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":91,"alignment:full":13415},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}