{"metadata":{"accession":"PF05018","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007714","hierarchy":null,"name":{"name":"CFA20 domain","short":"CFA20_dom"},"description":[{"text":"<p>This domain is characteristic of cilia- and flagella-associated protein 20 (CFA20). CFA20 is a cilium- and flagellum-specific protein that plays a role in axonemal structure organisation and motility [[cite:PUB00072946],[cite:PUB00072975]]. In Chlamydomonas reinhardtii, it stabilises outer doublet microtubules (DMTs) of the axoneme and may work as a scaffold for intratubular proteins, such as tektin and PACRG, to produce the beak structures in DMT1 [[cite:PUB00072975],[cite:PUB00072976]]. Other proteins contain a domain with homology to CFA20. WDR90/POC16 contains such a domain in its N terminus, followed by a large C-terminal domain with multiple WD40 repeats [[cite:PUB00072975]]. This domain is also present in the N terminus of uncharacterised protein C3orf67.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00072976":{"PMID":24259666,"ISBN":null,"volume":"127","issue":"Pt 2","year":2014,"title":"The conserved ciliary protein Bug22 controls planar beating of Chlamydomonas flagella.","URL":null,"raw_pages":"281-7","medline_journal":"J Cell Sci","ISO_journal":"J. Cell. Sci.","authors":["Meng D","Cao M","Oda T","Pan J."],"DOI_URL":"http://dx.doi.org/10.1242/jcs.140723"},"PUB00072975":{"PMID":24574454,"ISBN":null,"volume":"25","issue":"9","year":2014,"title":"FAP20 is an inner junction protein of doublet microtubules essential for both the planar asymmetrical waveform and stability of flagella in Chlamydomonas.","URL":null,"raw_pages":"1472-83","medline_journal":"Mol Biol Cell","ISO_journal":"Mol. Biol. Cell","authors":["Yanagisawa HA","Mathis G","Oda T","Hirono M","Richey EA","Ishikawa H","Marshall WF","Kikkawa M","Qin H."],"DOI_URL":"http://dx.doi.org/10.1091/mbc.E13-08-0464"},"PUB00072946":{"PMID":20118210,"ISBN":null,"volume":"9","issue":"4","year":2010,"title":"Bug22p, a conserved centrosomal/ciliary protein also present in higher plants, is required for an effective ciliary stroke in Paramecium.","URL":null,"raw_pages":"645-55","medline_journal":"Eukaryot Cell","ISO_journal":"Eukaryotic Cell","authors":["Laligne C","Klotz C","de Loubresse NG","Lemullois M","Hori M","Laurent FX","Papon JF","Louis B","Cohen J","Koll F."],"DOI_URL":"http://dx.doi.org/10.1128/EC.00368-09"}},"set_info":{"accession":"CL0202","name":"GBD"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":223,"interactions":0,"matches":6394,"pathways":0,"proteins":5992,"proteomes":2195,"sets":1,"structural_models":{"alphafold":4438},"structures":28,"taxa":6576},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":29,"alignment:full":4963},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}