{"metadata":{"accession":"PF04802","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR006887","hierarchy":null,"name":{"name":"Phosphatase 4 regulatory subunit 3","short":"PP4R3"},"description":[{"text":"<p>This entry represents the Serine/threonine-protein phosphatase 4 regulatory subunit 3 (also known as SMEK homologue) PP4R3, which forms a complex with the phosphatase 4 catalytic subunit (PP4c), localising it to the DNA damage repair machinery [[cite:PUB00101025],[cite:PUB00035452],[cite:PUB00101024],[cite:PUB00101026]] and regulates its activity. PP4c is involved in developmental progression, chemotaxis, expression of stress response genes and cell movement. These proteins contain an N-terminal EVH1 domain and this alpha solenoid region.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00101026":{"PMID":20951350,"ISBN":null,"volume":"19","issue":"4","year":2010,"title":"A Mec1- and PP4-dependent checkpoint couples centromere pairing to meiotic recombination.","URL":null,"raw_pages":"599-611","medline_journal":"Dev Cell","ISO_journal":"Dev Cell","authors":["Falk JE","Chan AC","Hoffmann E","Hochwagen A."],"DOI_URL":null},"PUB00101025":{"PMID":16530049,"ISBN":null,"volume":"124","issue":"5","year":2006,"title":"SMK-1, an essential regulator of DAF-16-mediated longevity.","URL":null,"raw_pages":"1039-53","medline_journal":"Cell","ISO_journal":"Cell","authors":["Wolff S","Ma H","Burch D","Maciel GA","Hunter T","Dillin A."],"DOI_URL":null},"PUB00035452":{"PMID":16857015,"ISBN":null,"volume":"273","issue":"14","year":2006,"title":"The Saccharomyces cerevisiae orthologue of the human protein phosphatase 4 core regulatory subunit R2 confers resistance to the anticancer drug cisplatin.","URL":null,"raw_pages":"3322-34","medline_journal":"FEBS J","ISO_journal":"FEBS J.","authors":["Hastie CJ","Vazquez-Martin C","Philp A","Stark MJ","Cohen PT."],"DOI_URL":"http://dx.doi.org/10.1111/j.1742-4658.2006.05336.x"},"PUB00101024":{"PMID":16085932,"ISBN":null,"volume":"4","issue":"11","year":2005,"title":"A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity.","URL":null,"raw_pages":"1725-40","medline_journal":"Mol Cell Proteomics","ISO_journal":"Mol Cell Proteomics","authors":["Gingras AC","Caballero M","Zarske M","Sanchez A","Hazbun TR","Fields S","Sonenberg N","Hafen E","Raught B","Aebersold R."],"DOI_URL":null}},"set_info":{"accession":"CL0020","name":"TPR"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":100,"interactions":0,"matches":7908,"pathways":0,"proteins":7072,"proteomes":3343,"sets":1,"structural_models":{"alphafold":5987},"structures":0,"taxa":8840},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":90,"alignment:full":6218},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}