{"metadata":{"accession":"PF04765","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR048354","hierarchy":null,"name":{"name":"TOD1/MUCI70, glycosyltransferase-like domain","short":"TOD1_MUCI70"},"description":[{"text":"<p>This entry represents a glycosyltransferase-like domain found in alkaline ceramidase TOD1 and the probable hexosyltransferase MUCI70 from Arabidopsis. MUCI70 is a predicted glycosyltransferase essential for the accumulation of seed mucilage, a gelatinous wall rich in unbranched rhamnogalacturonan I (RG I), and for shaping the surface morphology of seeds [[cite:PUB00095110],[cite:PUB00101913]]. TOD1 is an  endoplasmic reticulum ceramidase that catalyses the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH (e.g. pH 9.5) [[cite:PUB00101912],[cite:PUB00101914]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00101914":{"PMID":33735469,"ISBN":null,"volume":"106","issue":"5","year":2021,"title":"Turgor regulation defect 1 proteins play a conserved role in pollen tube reproductive innovation of the angiosperms.","URL":null,"raw_pages":"1356-1365","medline_journal":"Plant J","ISO_journal":"Plant J","authors":["Ke CJ","Lin XJ","Zhang BY","Chen LY."],"DOI_URL":null},"PUB00101913":{"PMID":31591153,"ISBN":null,"volume":"181","issue":"4","year":2019,"title":"Natural Variation Reveals a Key Role for Rhamnogalacturonan I in Seed Outer Mucilage and Underlying Genes.","URL":null,"raw_pages":"1498-1518","medline_journal":"Plant Physiol","ISO_journal":"Plant Physiol","authors":["Fabrissin I","Cueff G","Berger A","Granier F","Salle C","Poulain D","Ralet MC","North HM."],"DOI_URL":null},"PUB00095110":{"PMID":30228108,"ISBN":null,"volume":"178","issue":"3","year":2018,"title":"Identification of Key Enzymes for Pectin Synthesis in Seed Mucilage.","URL":null,"raw_pages":"1045-1064","medline_journal":"Plant Physiol","ISO_journal":"Plant Physiol.","authors":["Voiniciuc C","Engle KA","Gunl M","Dieluweit S","Schmidt MH","Yang JY","Moremen KW","Mohnen D","Usadel B."],"DOI_URL":null},"PUB00101912":{"PMID":25591940,"ISBN":null,"volume":"6","issue":null,"year":2015,"title":"The Arabidopsis alkaline ceramidase TOD1 is a key turgor pressure regulator in plant cells.","URL":null,"raw_pages":"6030","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Chen LY","Shi DQ","Zhang WJ","Tang ZS","Liu J","Yang WC."],"DOI_URL":null}},"set_info":{"accession":"CL0110","name":"GT-A"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":126,"interactions":0,"matches":5706,"pathways":0,"proteins":5489,"proteomes":686,"sets":1,"structural_models":{"alphafold":4377},"structures":0,"taxa":1874},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":30,"alignment:full":3682},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}