This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells [[cite:PUB00019508]]. ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"ELMO_(protein)","extract":"ELMO is a family of related proteins (~82 kDa) involved in intracellular signalling networks. These proteins have no intrinsic catalytic activity and instead function as adaptors which can regulate the activity of other proteins through their ability to mediate protein-protein interactions.
","thumbnail":null}],"literature":{"PUB00019508":{"PMID":11595183,"ISBN":null,"volume":"107","issue":"1","year":2001,"title":"CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.","URL":null,"raw_pages":"27-41","medline_journal":"Cell","ISO_journal":"Cell","authors":["Gumienny TL","Brugnera E","Tosello-Trampont AC","Kinchen JM","Haney LB","Nishiwaki K","Walk SF","Nemergut ME","Macara IG","Francis R","Schedl T","Qin Y","Van Aelst L","Hengartner MO","Ravichandran KS."],"DOI_URL":"http://dx.doi.org/10.1016/S0092-8674(01)00520-7"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":226,"interactions":0,"matches":14729,"pathways":0,"proteins":14425,"proteomes":3212,"sets":0,"structural_models":{"alphafold":12473},"structures":15,"taxa":8666},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":190,"alignment:full":11339},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}