{"metadata":{"accession":"PF04721","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR006588","hierarchy":null,"name":{"name":"PNGase C-terminal domain, mannose-binding module PAW","short":"PAW"},"description":[{"text":"<p>The PAW domain is found at the C-terminus of PGNase, or peptide-N-glycanase, enzymes. It was named for 'domain present in PNGases and other worm proteins' [[cite:PUB00011448]]. PNGase catalyses the deglycosylation of several misfolded N-linked glycoproteins by cleaving off the bulky glycan chain before these proteins are degraded by the proteasome. PNGase specifically acts on the unfolded form of high-mannose type N-glycosylated proteins, and this domain appears to be the mannose-binding domain, which contributes to the oligosaccharide-binding specificity of PNGase [[cite:PUB00041628]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00011448":{"PMID":11779830,"ISBN":null,"volume":"12","issue":"1","year":2002,"title":"Systematic identification of novel protein domain families associated with nuclear functions.","URL":null,"raw_pages":"47-56","medline_journal":"Genome Res","ISO_journal":"Genome Res.","authors":["Doerks T","Copley RR","Schultz J","Ponting CP","Bork P."],"DOI_URL":"http://dx.doi.org/10.1101/gr.203201"},"PUB00041628":{"PMID":17088551,"ISBN":null,"volume":"103","issue":"46","year":2006,"title":"Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module.","URL":null,"raw_pages":"17214-9","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Zhou X","Zhao G","Truglio JJ","Wang L","Li G","Lennarz WJ","Schindelin H."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.0602954103"}},"set_info":{"accession":"CL0202","name":"GBD"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":58,"interactions":0,"matches":1671,"pathways":0,"proteins":1623,"proteomes":991,"sets":1,"structural_models":{"alphafold":1367},"structures":3,"taxa":3432},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":33,"alignment:full":1214},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2g9f","name":"Crystal structure of intein-tagged mouse PNGase C-terminal domain"}}}