{"metadata":{"accession":"PF04678","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR006769","hierarchy":null,"name":{"name":"Mitochondrial calcium uniporter","short":"MCU"},"description":[{"text":"<p>MCU functions with MICU1, an essential gatekeeper component of calcium-channel transport, to facilitate Ca2+ uptake into the mitochondrion [[cite:PUB00088836],[cite:PUB00109160],[cite:PUB00081393]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Mitochondrial_calcium_uniporter","extract":"<p>The <b>mitochondrial calcium uniporter</b> (<b>MCU</b>) is a transmembrane protein that allows the passage of calcium ions from a cell's cytosol into mitochondria. Its activity is regulated by MICU1 and MICU2, which together with the MCU make up the mitochondrial calcium uniporter complex.</p>","thumbnail":null}],"literature":{"PUB00088836":{"PMID":21685888,"ISBN":null,"volume":"476","issue":"7360","year":2011,"title":"A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.","URL":null,"raw_pages":"336-40","medline_journal":"Nature","ISO_journal":"Nature","authors":["De Stefani D","Raffaello A","Teardo E","Szabo I","Rizzuto R."],"DOI_URL":"https://doi.org/10.1038/nature10230"},"PUB00081393":{"PMID":24231807,"ISBN":null,"volume":"342","issue":"6164","year":2013,"title":"EMRE is an essential component of the mitochondrial calcium uniporter complex.","URL":null,"raw_pages":"1379-82","medline_journal":"Science","ISO_journal":"Science","authors":["Sancak Y","Markhard AL","Kitami T","Kovacs-Bogdan E","Kamer KJ","Udeshi ND","Carr SA","Chaudhuri D","Clapham DE","Li AA","Calvo SE","Goldberger O","Mootha VK."],"DOI_URL":"http://dx.doi.org/10.1126/science.1242993"},"PUB00076354":{"PMID":23178883,"ISBN":null,"volume":"14","issue":"12","year":2012,"title":"MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.","URL":null,"raw_pages":"1336-43","medline_journal":"Nat Cell Biol","ISO_journal":"Nat. Cell Biol.","authors":["Mallilankaraman K","Cardenas C","Doonan PJ","Chandramoorthy HC","Irrinki KM","Golenar T","Csordas G","Madireddi P","Yang J","Muller M","Miller R","Kolesar JE","Molgo J","Kaufman B","Hajnoczky G","Foskett JK","Madesh M."],"DOI_URL":"http://dx.doi.org/10.1038/ncb2622"},"PUB00109160":{"PMID":21934651,"ISBN":null,"volume":"30","issue":"20","year":2011,"title":"After half a century mitochondrial calcium in- and efflux machineries reveal themselves.","URL":null,"raw_pages":"4119-25","medline_journal":"EMBO J","ISO_journal":"EMBO J","authors":["Drago I","Pizzo P","Pozzan T."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":74,"interactions":0,"matches":6501,"pathways":0,"proteins":6482,"proteomes":2787,"sets":0,"structural_models":{"alphafold":5562},"structures":16,"taxa":7574},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":76,"alignment:full":4762},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}