{"metadata":{"accession":"PF04672","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR006764","hierarchy":null,"name":{"name":"S-adenosyl methyltransferase","short":"Methyltransf_19"},"description":[{"text":"<p>This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure PDB:3giw from [swissprot:Q82L35] suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22 . The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00152210":{"PMID":18154359,"ISBN":null,"volume":"47","issue":"3","year":2008,"title":"The histamine N-methyltransferase T105I polymorphism affects active site structure and dynamics.","URL":null,"raw_pages":"893-901","medline_journal":"Biochemistry","ISO_journal":"Biochemistry","authors":["Rutherford K","Parson WW","Daggett V."],"DOI_URL":"https://doi.org/10.1021/bi701737f"}},"set_info":{"accession":"CL0063","name":"NADP_Rossmann"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":36,"interactions":0,"matches":17521,"pathways":0,"proteins":17491,"proteomes":1897,"sets":1,"structural_models":{"alphafold":9288},"structures":3,"taxa":2351},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":12,"alignment:full":7988},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3giw","name":"CRYSTAL STRUCTURE OF a DUF574 family protein (SAV_2177) FROM STREPTOMYCES AVERMITILIS MA-4680 AT 1.45 A RESOLUTION"}}}