The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes [[cite:PUB00069342]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Calcium-dependent_chloride_channel","extract":"The Calcium-Dependent Chloride Channel (Ca-ClC) proteins (or calcium-activated chloride channels, are heterogeneous groups of ligand-gated ion channels for chloride that have been identified in many epithelial and endothelial cell types as well as in smooth muscle cells. They include proteins from several structurally different families: chloride channel accessory, bestrophin, and calcium-dependent chloride channel anoctamin channels ANO1 is highly expressed in human gastrointestinal interstitial cells of Cajal, which are proteins which serve as intestinal pacemakers for peristalsis. In addition to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors. These eukaryotic proteins are \"required for normal electrolyte and fluid secretion, olfactory perception, and neuronal and smooth muscle excitability\" in animals. Members of the Ca-CIC family are generally 600 to 1000 amino acyl residues in length and exhibit 7 to 10 transmembrane segments.
","thumbnail":null}],"literature":{"PUB00069342":{"PMID":18724360,"ISBN":null,"volume":"455","issue":"7217","year":2008,"title":"TMEM16A confers receptor-activated calcium-dependent chloride conductance.","URL":null,"raw_pages":"1210-5","medline_journal":"Nature","ISO_journal":"Nature","authors":["Yang YD","Cho H","Koo JY","Tak MH","Cho Y","Shim WS","Park SP","Lee J","Lee B","Kim BM","Raouf R","Shin YK","Oh U."],"DOI_URL":"http://dx.doi.org/10.1038/nature07313"}},"set_info":{"accession":"CL0416","name":"Anoctamin-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":348,"interactions":0,"matches":25823,"pathways":0,"proteins":24367,"proteomes":3289,"sets":1,"structural_models":{"alphafold":20769},"structures":78,"taxa":8741},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":284,"alignment:full":20324},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}