This family was first named TPM domain after its founding proteins: TLP18.3, Psb32 and MOLO-1. In Arabidopsis, this domain is called the thylakoid acid phosphatase -TAP - domain and has a Rossmann-like fold [[cite:PUB00056969]]. In plants, the family resides in the thylakoid lumen attached to the outer membrane of the chloroplast/plastid. It is active in the photosystem II [[cite:PUB00057495],[cite:PUB00078747]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"TPM_domain","extract":"The TPM domain family is named after the three founding proteins TLP18.3, Psb32 and MOLO-1. TPM domains have a characteristic alpha-helical fold and flanking four central β strands. The TPM fold has not been found in other protein domains to date. TPM was previously referred to as \"DUF477\" and \"Repair_PSII\".
","thumbnail":null}],"literature":{"PUB00057495":{"PMID":17576201,"ISBN":null,"volume":"406","issue":"3","year":2007,"title":"TLP18.3, a novel thylakoid lumen protein regulating photosystem II repair cycle.","URL":null,"raw_pages":"415-25","medline_journal":"Biochem J","ISO_journal":"Biochem. J.","authors":["Sirpio S","Allahverdiyeva Y","Suorsa M","Paakkarinen V","Vainonen J","Battchikova N","Aro EM."],"DOI_URL":"http://dx.doi.org/10.1042/BJ20070460"},"PUB00056969":{"PMID":21908686,"ISBN":null,"volume":"157","issue":"3","year":2011,"title":"Structural and Functional Assays of AtTLP18.3 Identify Its Novel Acid Phosphatase Activity in Thylakoid Lumen.","URL":null,"raw_pages":"1015-25","medline_journal":"Plant Physiol","ISO_journal":"Plant Physiol.","authors":["Wu HY","Liu MS","Lin TP","Cheng YS."],"DOI_URL":"http://dx.doi.org/10.1104/pp.111.184739"},"PUB00078747":{"PMID":21653280,"ISBN":null,"volume":"4","issue":"6","year":2011,"title":"The Psb32 protein aids in repairing photodamaged photosystem II in the cyanobacterium Synechocystis 6803.","URL":null,"raw_pages":"1052-61","medline_journal":"Mol Plant","ISO_journal":"Mol Plant","authors":["Wegener KM","Bennewitz S","Oelmuller R","Pakrasi HB."],"DOI_URL":"http://dx.doi.org/10.1093/mp/ssr044"}},"set_info":{"accession":"CL0063","name":"NADP_Rossmann"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":53,"interactions":0,"matches":17474,"pathways":0,"proteins":17406,"proteomes":9807,"sets":1,"structural_models":{"alphafold":11136},"structures":12,"taxa":14697},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":377,"alignment:full":8715},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"7tbr","name":"Crystal structure of the TPM domain from the Rhodothermus marinus protein Rhom172_1776"}}}