{"metadata":{"accession":"PF04463","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007553","hierarchy":null,"name":{"name":"2-thiouracil desulfurase","short":"2-thiour_desulf"},"description":[{"text":"<p>This family of proteins, predominantly found in Bacteria, are involved in the desulfuration of 2-thiouracil into uracil in the 2-thiouridine degradation pathway. It has been demonstrated that these proteins contain a Fe-S cluster required for their activity [[cite:PUB00098595]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00098595":{"PMID":29194984,"ISBN":null,"volume":"10","issue":"1","year":2018,"title":"A gene encoding a DUF523 domain protein is involved in the conversion of 2-thiouracil into uracil.","URL":null,"raw_pages":"49-56","medline_journal":"Environ Microbiol Rep","ISO_journal":"Environ Microbiol Rep","authors":["Aucynaite A","Rutkiene R","Gasparaviciute R","Meskys R","Urbonavicius J."],"DOI_URL":null}},"set_info":{"accession":"CL1003","name":"TudS"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":21,"interactions":0,"matches":6456,"pathways":0,"proteins":6456,"proteomes":5023,"sets":1,"structural_models":{"alphafold":4053},"structures":5,"taxa":7714},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":257,"alignment:full":2711},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6z96","name":"[4Fe-4S]-dependent thiouracil desulfidase TudS (DUF523Vcz) soaked with 4-thiouracil (12.65 keV, 7.125 keV (Fe-SAD) and 6.5 keV (S-SAD) data)"}}}