{"metadata":{"accession":"PF04447","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007538","hierarchy":null,"name":{"name":"dATP/dGTP pyrophosphohydrolase","short":"dATP-dGTP_PPHyd"},"description":[{"text":"<p>This domain is found in phage proteins, such as A0A2H5BHG5 from Acinetobacter phage SH-Ab 15497, which are associated with PurZ, an enzyme that catalyses the synthesis of diaminopurine (Z), a DNA modification that gives phages an advantage for evading host restriction enzymes activity [[cite:PUB00097959]]. This domain has dATP and dGTP pyrophosphohydrolase activity; it catalyses the hydrolysis of dATP/dGTP to pyrophosphate and dAMP/dGMP, respectively, with little or no activities for NTPs and pyrimidine dNTPs. It is suggested that enzymes containing this domain supply dGMP as the substrate for PurZ, elevating dZTP level to promote Z incorporation [[cite:PUB00097959]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00097959":{"PMID":33926954,"ISBN":null,"volume":"372","issue":"6541","year":2021,"title":"A widespread pathway for substitution of adenine by diaminopurine in phage genomes.","URL":null,"raw_pages":"512-516","medline_journal":"Science","ISO_journal":"Science","authors":["Zhou Y","Xu X","Wei Y","Cheng Y","Guo Y","Khudyakov I","Liu F","He P","Song Z","Li Z","Gao Y","Ang EL","Zhao H","Zhang Y","Zhao S."],"DOI_URL":null}},"set_info":{"accession":"CL0231","name":"MazG"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":10,"interactions":0,"matches":204,"pathways":0,"proteins":202,"proteomes":188,"sets":1,"structural_models":{"alphafold":83},"structures":1,"taxa":506},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":130},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"7ody","name":"Cyanophage S-2L MazG-like pyrophosphohydrolase bound to dGDP and three catalytic Mn2+ ions per active site"}}}