This is a large family of uncharacterised proteins found in all domains of life. The structure shows a novel fold with three beta sheets. A dimeric form is found in the crystal structure. It was suggested that the cleft in between the two monomers might bing nucleic acid [[cite:PUB00019473]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00019473":{"PMID":11746696,"ISBN":null,"volume":"45","issue":"4","year":2001,"title":"X-ray crystal structure of MTH938 from Methanobacterium thermoautotrophicum at 2.2 A resolution reveals a novel tertiary protein fold.","URL":null,"raw_pages":"486-8","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Das K","Xiao R","Wahlberg E","Hsu F","Arrowsmith CH","Montelione GT","Arnold E."],"DOI_URL":"http://dx.doi.org/10.1002/prot.1162"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":80,"interactions":0,"matches":8559,"pathways":0,"proteins":8557,"proteomes":7131,"sets":0,"structural_models":{"alphafold":6673},"structures":9,"taxa":14086},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":221,"alignment:full":5743},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2cyj","name":"Crystal structure of conserved hypothetical protein PH1505 from Pyrococcus horikoshii OT3"}}}