This family of short eukaryotic proteins has no known function. Most of the members of this family are only 80 amino acid residues long. However the Arabidopsis homologue is over 300 residues long. The presumed domain contains a conserved amino terminal cysteine and a conserved motif GXGXGXG in the carboxy terminal half that may be functionally important.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":41,"interactions":0,"matches":3910,"pathways":0,"proteins":3901,"proteomes":2958,"sets":0,"structural_models":{"alphafold":3396},"structures":0,"taxa":7989},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":43,"alignment:full":2962},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}